Can We Slow Down Aging? The Science of Longevity and Healthspan

In this fascinating episode, Dr. Debbie Ozment, DDS, sits down with Dr. Nir Barzilai, a leading researcher in aging, to explore the science behind longevity and what truly influences our health as we age. Dr. Barzilai explains why biological age—rather than chronological age—is the key factor in determining health and lifespan. He discusses how aging drives diseases and how targeting aging at a biological level could help prevent many chronic conditions. The episode explores the interconnected hallmarks of aging, including metabolism, inflammation, immunity, epigenetics, and the microbiome. Dr. Barzilai highlights how addressing any of these hallmarks can positively affect others, paving the way for healthier aging. Dr. Barzilai also discusses the role of metformin, not as a miracle cure but as proof that aging can be targeted. He shares insights into its potential benefits beyond glucose control, such as its effects on immunity and inflammation. Beyond medications, he emphasizes the importance of lifestyle choices, such as exercise, diet (including intermittent fasting), sleep, and social connectivity, in slowing down the aging process. He shares his personal habits and the wisdom he has gathered from studying centenarians. Looking ahead, Dr. Barzilai is focused on advancing research to measure biological age through biomarkers and protein analysis. He also explores emerging discoveries, such as the impact of stress as a new hallmark of aging and the influential role of social connections in extending lifespan. Tune in to discover the latest scientific breakthroughs in aging and practical strategies to enhance your healthspan!